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Anyone have a dog with Lupus? And what medications worked?
07-24-2016, 07:25 PM,
#1
Anyone have a dog with Lupus? And what medications worked?
    My dog BABY has Lupus and was diagnosed in November of 2015. We have used many medications to try and keep her Lupus in remission, however, no safe combination has been able to do that. She has been on at one time or another.....Prednisone, Methylprednisolone, Atopica, Azathioprine, Mycophenolate, Pentoxifylline and none of them will keep her Lupus oral lesions and ulcers in remission. The Lupus lesions and ulcers on her feet and rear legs are OK but the oral lesions (soft palate, gums, and inner lip tissue) will not stay in remission or even go into full remission even on high dose steroids.

If someone has tried other medications that have helped Lupus, please let me know so that I can discuss with Derm. Dr.

We are running out of time as she has been on medication since last 




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More info about BABY's Lupus at https://www.facebook.com/SickMinPin/ & http://sickminpin.weebly.com/
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07-25-2016, 03:01 PM,
#2
RE: Anyone have a dog with Lupus? And what medications worked?
My dog doesn't have lupus, but I know for a fact how challenging it is to manage this autoimmune disease. I hope something helpful comes your way.
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07-25-2016, 03:04 PM,
#3
RE: Anyone have a dog with Lupus? And what medications worked?
(07-25-2016, 03:01 PM)Jennifer Wrote: My dog doesn't have lupus, but I know for a fact how challenging it is to manage this autoimmune disease. I hope something helpful comes your way.

Thank you Jennifer for the kind words
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07-26-2016, 12:58 PM,
#4
RE: Anyone have a dog with Lupus? And what medications worked?
The drugs being used suggests the Vet has diagnosed the SLE, instead of the DLE form

Azathioprine, and Prednisone are the mainstays for SLE treatment. Sometimes other immuno suppressive drugs such as Cytoxan are used.

Sometimes doxycycline plus niacin typically used for the DLE form are added in to help with the skin ulcer problems.

http://veterinarycalendar.dvm360.com/lup...roceedings

I'm giving one of my dogs doxycycline (not a lupus puppy), and it's causing apparent anorexic problems. Something to be aware of if that antibiotic is prescribed for the skin problems.

Omega 3s are said to be a slight help as a supplement. Throw in 6000 mg of fish oil into the diet. It has very mild anti-inflammatory properties.
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07-26-2016, 04:33 PM,
#5
RE: Anyone have a dog with Lupus? And what medications worked?
(07-26-2016, 12:58 PM)dragondawg Wrote: The drugs being used suggests the Vet has diagnosed the SLE, instead of the DLE form

Azathioprine, and Prednisone are the mainstays for SLE treatment.  Sometimes other immuno suppressive drugs such as Cytoxan are used.

Sometimes doxycycline plus niacin typically used for the DLE form are added in to help with the skin ulcer problems.

http://veterinarycalendar.dvm360.com/lup...roceedings

I'm giving one of my dogs doxycycline (not a lupus puppy), and it's causing apparent anorexic problems.  Something to be aware of if that antibiotic is prescribed for the skin problems.

Omega 3s are said to be a slight help as a supplement.  Throw in 6000 mg of fish oil into the diet.  It has very mild anti-inflammatory properties.

Thank you for your response.

The dermatologists does lean way towards Cutaneous but the DLE cases they have had recently have not responded to treatment very well. I know when she was first diagnosed with lupus i went online and read over and over how DLE had a good prognosis, however, the specialists say that they don't always find that and cutaneous can be very hard and sometimes impossible to manage depending on the variety of DLE and the animal. I was reading on that link you posted but had to stop when they said DLE always starts on the nose. I will have to look up some of the other meds above and check them out but I think those are just antibiotics and I think we got that covered with chlorhexidine pads. When I spoke with the Dr at Elanco the other day, she said that the Atopica was not helping much with the difficult Cutaneous cases such as with BABY. BABY had been on a Omega 3 supplement for the past few years (for skin allergies) and it seemed to help but when the lupus exploded last november the Derm Dr wanted her off everything to make sure she was not allergic to one of her meds. A few months ago I tried giving her the Omega 3 vitamin again and she had a severe reaction. Ran to the Atopica insert and found they sometimes cause that when given with same treatment so we had to stay away from that. Unfortunately BABY was on a short term low dosage of prednisone for her severe allergies at the time we went to the derm dr so there was no way to test to see if she had a SLE variety or not. Even at best, the ANA is only somewhat reliable since they do find many false negatives. My opinion from what I have seen with BABY's other signs and symptoms is that I felt it was SLE but Lupus is so tricky that it fools the best of them. The Derm Dr. has ran regular blood panels on her several times and one just about 3 weeks ago and it all came back WNL with nothing that would support a systemic variety. Since BABY has probably shown signs of lupus for several years the blood work would of shown a couple of things for which I cannot remember. So I have just accepted that its either a very aggressive form of Cutaneous lupus or a SLE variety that is not causing any internal damage or changes.

I remember when she was first diagnosed from the biopsies of her metatarsal pads. I did not believe it was lupus and everything I read from reputable web sites said it almost always started on the nose and BABY had nothing on the nose at all so I thought the Vets were just guessing as usual. But after talking to many Vets that had actually treated Lupus, I found that it can start anywhere and look like anything. So then I started believing the Derm Dr. that it was indeed lupus.

I may have actually found an answer to what we need. A human Lupie told me about something called "Magic Mouthwash". I looked it up and they have it for all sorts of conditions and several formulas for lupus and the Lupies swear by it and said its the one thing they could not live without. So, I am hoping that I can find a formula that is already made up for lupus dogs and if not, then the Drs. and I will be looking into getting something made up for BABY. The human formulas are too strong and have dog toxic ingredients so it may be a challenge to get this for her but we will. If we can control the lupus in her mouth, then we can get her off the steroids and start skipping days on Atopica. The mouth lesions are the only ones that seem to pop up when we lower the steroids to a safe level.

That was a great idea you had about the Omega 3 fatty acids. Unfortunately they don't set well with BABY while on the Atopica and we probably dont have the months and months it takes for them to start working.

Thank you for your response and ideas
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07-27-2016, 04:02 PM,
#6
RE: Anyone have a dog with Lupus? And what medications worked?
I've never heard of the Omega-3s (fish oil) causing a reaction. Maybe there was something else (e.g. contaminant such as iodine) in the specific "supplement" the dog was allergic to?

Here is a research article abstract from 2015, you can discuss with your attending Vet :

"A diagnosis of generalized DLE was made based on the clinical presentation, histopathology, laboratory values, and direct immunofluorescence findings. Treatment consisted of oral tetracycline and oral niacinamide, which resulted in complete remission of clinical signs. This is the first documented report of generalized canine DLE responding to the described immunomodulating regimen. Such a combination might therefore be considered as a glucocorticoid and/or antimalarial alternative for the management of generalized DLE. "

http://www.ncbi.nlm.nih.gov/pubmed/25955142

Also might want to discuss Vitamin-E with the Vet, and how it would interact with other treatment drugs, or the disease itself. Sometimes Vitamins are an add, sometimes evil in their interactions with drugs.
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07-27-2016, 05:12 PM,
#7
RE: Anyone have a dog with Lupus? And what medications worked?
(07-27-2016, 04:02 PM)dragondawg Wrote: I've never heard of the Omega-3s (fish oil) causing a reaction.  Maybe there was something else (e.g. contaminant such as iodine) in the specific "supplement" the dog was allergic to?  

Here is a research article abstract from 2015, you can discuss with your attending Vet :

"A diagnosis of generalized DLE was made based on the clinical presentation, histopathology, laboratory values, and direct immunofluorescence findings. Treatment consisted of oral tetracycline and oral niacinamide, which resulted in complete remission of clinical signs. This is the first documented report of generalized canine DLE responding to the described immunomodulating regimen. Such a combination might therefore be considered as a glucocorticoid and/or antimalarial alternative for the management of generalized DLE. "

http://www.ncbi.nlm.nih.gov/pubmed/25955142

Also might want to discuss Vitamin-E with the Vet, and how it would interact with other treatment drugs, or the disease itself.  Sometimes Vitamins are an add, sometimes evil in their interactions with drugs.

Unfortunately BABY is allergic to a lot of stuff and then with the Lupus actually causing those reactions to be more severe and the Atopica on top of that, it just doesn't mix weill with her case.


dragondawg, the one things you need to know about lupus is that no 2 cases are alike and each case of lupus is specific to that individual. There are millions of variations of the 4 forms of canine lupus. In our case as I stated, we don't have the months and months to wait for a vitamin to start working and are looking for something that will help before she dies. The very worst thing someone trying to find out about lupus can do is look up stuff online. 99% of it is wrong, ask any good dermatologist or immunologist. I used to look up stuff online like you do but I soon found out that its better to listen to the very doctors that are treating lupus over and over instead of reading stuff online that is not reliable.

As I said in my last post, the doctors are working on a oral formula to add to her regimen which has been found to work well when only the oral lesions are flaring. 

Thanks for the link but I just don't have time to read up on old news that is not reliable.
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07-28-2016, 09:43 AM,
#8
RE: Anyone have a dog with Lupus? And what medications worked?
" I just don't have time to read up on old news that is not reliable."

The link was to an abstract of an article published in the Journal of American Animal Hospital Association. It's a Vet research Journal, which published a DLE treatment article in 2015. The 4 authors all DVMs with 3/4 DACVD (Diplomate American College of Veterinary Dermatology ) accreditations. That should instill a little reliability into their research results. The chances are better than even your Vet(s) may have read either that article or previous ones concerning the Doxycycline+Niacin treatment for DLE. Maybe they have already ruled it out as inappropriate for your dog. Or believe there are other treatments yet to be tried first. The only way to know is to ask them.

GL to you and your puppy dog.
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07-30-2016, 03:05 AM,
#9
RE: Anyone have a dog with Lupus? And what medications worked?
Dragondawg really provided reliable sources. Hopefully somebody with this same disorder can chime in but it's not a common condition and even among humans there doesn't seem to be much in terms of a cure for lupus. I hope the formula your vets are working on will help. Keep us posted.
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03-06-2017, 06:08 PM,
#10
RE: Anyone have a dog with Lupus? And what medications worked?
(07-30-2016, 03:05 AM)meba Wrote: Dragondawg really provided reliable sources. Hopefully somebody with this same disorder can chime in but it's not a common condition and even among humans there doesn't seem to be much in terms of a cure for lupus. I hope the formula your vets are working on will help. Keep us posted.

I also need help with a dog that has been diagnosed with Lupus - at first a combination of Atopica and Rimadyl was the answer - after about 5 months - my Chesney's nose started to flare up again - he also has a couple of sores on his foot (he had to have a mass removed) that have not healed (primarily due to licking!!)   I've stopped the Atopica just to see if there is any change - i've continued the Rimadyl - any homeopathic ideas - anything.....he's not bothered at all - but his poor nose looks horrible??
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