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Conjunctival viral papilloma
01-13-2017, 12:34 AM,
#1
Conjunctival viral papilloma
Hi all,

We have a two year old Bernese Mountain dog who is an amazing dog who has always had little health issues. He was born with heart murmur which resolved in under 6 months, has food allergies and now hasn't issues with his eye. In August we noticed a small bump within the middle bottom of his eye that grew and we were referred to an eye specialist. That doctor recommended we get it removed and tested so we did and the results came back that it was a viral conjunctivitis or papilloma.  It was removed and by around mid December we noticed another bump to the right of where the last one was. It is growing faster and now we are going back to the eye specialist to see what to do next. We suspect he may have a little immune system and they say that when that gets stronger you could fight this off, so we wonder if letting it run its course maybe better as well.  The first picture I'm trying to post it's in the middle and all white and pink that was the first time, this new one now has both pink and black which makes us a bit nervous as well


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01-13-2017, 12:37 AM,
#2
RE: Conjunctival viral papilloma
Picture missing here is the most current one. [img]webkit-fake-url://b05142f9-c7f4-45ac-815a-481b5985dc49/imagepng[/img]
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01-13-2017, 03:06 PM,
#3
RE:Conjunctival viral papilloma
(01-13-2017, 12:34 AM)Sarahjay Wrote: Hi all,

We have a two year old Bernese Mountain dog who is an amazing dog who has always had little health issues. He was born with heart murmur which resolved in under 6 months, has food allergies and now hasn't issues with his eye. In August we noticed a small bump within the middle bottom of his eye that grew and we were referred to an eye specialist. That doctor recommended we get it removed and tested so we did and the results came back that it was a viral conjunctivitis or papilloma.  It was removed and by around mid December we noticed another bump to the right of where the last one was. It is growing faster and now we are going back to the eye specialist to see what to do next. We suspect he may have a little immune system and they say that when that gets stronger you could fight this off, so we wonder if letting it run its course maybe better as well.  The first picture I'm trying to post it's in the middle and all white and pink that was the first time, this new one now has both pink and black which makes us a bit nervous as well

Unfortunately the BM breed is one which has problems with the papilloma virus(es).  As in a genetic fault in the breed.  Most dogs have mature immune systems at 1-2 yrs.  Either this is the last round of growths,  or your dog may continue to have these warts the rest of its life.  Where they will come and go dependent on such things as stress affecting the immune system.  Along with the aging of the immune system.  If it's growing fast, then there's the possibility of irritation, infection, and then the opportunistic bacteria infection arrives.  Where one would need ocular antibiotics for the bacteria.  Then you could discuss with the Vet specialist whether to give it time to go away on its own or not.  Also to confirm it's still papilloma induced, and not something more serious.

If your dog is prepossessed to have a genetically weak immune system, then you'll have to be on guard for health problems associated in future years.  Everything from demodex mites to cancer as the dog ages.

When you see the Vet specialist, ask if Imiquimod is available as an ocular solution for dogs.  It's typically applied to skin&oral warts as a cream.  It helps stimulate the host animal to produce interferon. But unknown if it's used for ocular associated warts.  Also ask if the 10 day treatment of giving Azithromycin for oral&skin papilloma in dogs has any efficacy for ocular papilloma?  How the Azithromycin works in clearing up oral&skin warts is unknown.  Also, unclear if it has ever been tried for papilloma induced ocular warts. No evidence of trials, but your doggy Ophthalmologist may or may not know of one. Here's a recent article on Azithromycin, and it's use against skin&oral doggy warts.

https://www.researchgate.net/publication...ical_trial

It's something you can discuss with your doggy Ophthalmologist.

P.S.  My 13 yr 8 month puppy has a tiny pink growth on the lining of her eye.  It seems to grow, and recede in tiny amounts.  Also have a watch on a tiny cherry red pimple on her nose.  Very near where a rattlesnake nailed her 8 yrs ago.
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01-13-2017, 06:41 PM,
#4
RE: Conjunctival viral papilloma
Thanks so much for this reply. We have appointment Tuesday with specialist and I will bring your points with me.
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01-14-2017, 07:22 PM,
#5
RE: Conjunctival viral papilloma
I have been following this thread. Good luck on your appointment with the eye specialist, keep us posted.
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01-15-2017, 01:03 PM,
#6
RE: Conjunctival viral papilloma
Thanks so much. We will keep you updated. I am worried the doctor will say surgery for lack of better idea as this is an eye specialist not virologist and I've asked if they knew of vaccine and they said no. I would like it gone as well but can't be easy on Waylon to have surgery every three months and also worried we are not letting his body react to and defeat it. Tuesday is close so hopefully more answers to come. The most recent picture shows it's growth and odd characteristics but this chat says too big to upload - if anyone wants to see that to get better idea I can send directly to you. Thanks all
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01-17-2017, 12:34 AM,
#7
RE: Conjunctival viral papilloma
When I click on the picture above it enlarges and zooms up to almost three times its size of the thumbnail. The picture is pretty clear, looks like a wart only that instead of appearing on the dog's lips or mouth, it's by the eyelid area. if it interferes with vision and irritates the eye, surgery seems the route to go, but hopefully there may be something to try to shrink it. I know a vet that did a small eye procedure with a laser to remove a meibomian gland mass and it was pretty fast and the dog needed light anesthetic. Cryosurgery is also used sometimes.

Would be nice if it could be aspirated to have an exact idea of what it is before going through surgery.

If it's a wart, I wonder if a wart in en eye responds with slight crushing done by the vet? I know of vets who will crush papillomas so to stimulate the immune system, just not sure if this is feasible with one in the eye area. Usually, they tend to go away in 3-6 months. Anything that can stimulate the immune system may help. Bixbi immunity has some reviews saying that it has helped dogs with warts,not sure though if it's worth a try. Thuja has been found helpful in this study on papillomas in cattle:

http://www.veterinaryworld.org/Vol.5/Feb...Cattle.pdf
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01-17-2017, 02:40 PM,
#8
RE: Conjunctival viral papilloma
(01-17-2017, 12:34 AM)Thank you for the info, will take this with us today. My family has horses and this is common (on mouth as you said) with ponies, they crush them but family raised the same concern re: is that possible on the eye.The picture you saw in my post was his last one which was removed and diagnosed as a conjuntival viral papilloma (it wouldn\t let me post the new one but trying again). This one is larger now, is black, red and white (the other was pink and white) so all signs pointing to papilloma again, but we will see. My worry is that I don Wrote: When I click on the picture above it enlarges and zooms up to almost three times its size of the thumbnail. The picture is pretty clear, looks like a wart only that instead of appearing on the dog's lips or mouth, it's by the eyelid area. if it interferes with vision and irritates the eye, surgery seems the route to go, but hopefully there may be something to try to shrink it. I know a vet that did a small eye procedure with a laser to remove a meibomian gland mass and it was pretty fast and the dog needed light anesthetic. Cryosurgery is also used sometimes.

Would be nice if it could be aspirated to have an exact idea of what it is before going through surgery.

If it's a wart, I wonder if a wart in en eye responds with slight crushing done by the vet? I know of vets who will crush papillomas so to stimulate the immune system, just not sure if this is feasible with one in the eye area. Usually, they tend to go away in 3-6 months. Anything that can stimulate the immune system may help. Bixbi immunity has some reviews saying that it has helped dogs with warts,not sure though if it's worth a try. Thuja has been found helpful in this study on papillomas in cattle:

http://www.veterinaryworld.org/Vol.5/Feb...Cattle.pdf


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01-17-2017, 06:30 PM,
#9
RE: Conjunctival viral papilloma
Just got home from the vet. Appointment was good as they were on the same page (surgery may be necessary to make sure the eye is not an innocent bystander effected by this) that they think we should do more research so we don't just repeat a cycle of constant surgeries. I reached out to virologist at the university of guelph today and hoping they can shed some light.

Option we are going with right now is vet researches more, I do as well and I watch the eye carefully to determine when we have to remove just for his own sake. Amazingly, we have a bit oh hope. Waylon is a total lemon dog (God love him) so he is not without issues (pica, allergies, heart murmur at birth which went away under 6 months old) and he is on Apolquel for his allergies. This drug is new and high effective for allergies but an immunosuppresent which no one had connected before. He went on Apolquel June 7, 2016 and I first saw the tiny bump that would later grow into the first papilloma around August 29th. We are looking into this now, could be what is happening. Fingers crossed and stay tuned. 

I also really want to thank you two who have read and commented, this has been terrible and really nice knowing people are out there who have seen, are going through or can understand this kind of situation.
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01-17-2017, 08:32 PM,
#10
RE: Conjunctival viral papilloma
Hello Sarahjay,
I have been reading your posts and I think your vets are really up to something with the use of this drug potentially causing the warts! A simple search of "Apolquel and warts" brings several posts about people have your same issues with warts!
In this link below, which is the blog of Dr. Ron Hines..
http://www.2ndchance.info/Apoquel-Comments.htm
Quoted:
"I checked his paws and they were riddled with warts"
"Six days after sending me the above email, the owner reported that since discontinuing the Apoquel, the warts were shrinking"
"any increase in skin tags/warts (dermal papillomas), respiratory infections, skin infections or other infections, or changes in your pets white blood cell count and differential count might be early warning that the dose is too high"
" Just within the last week I noticed some warts around her eyes"
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